Semaglutide is a newer injectable drug approved by the Food and Drug Administration (FDA) to help obese adults lose weight and keep it off. Semaglutide weight loss works through GLP-1 agonism, or the stimulation of glucagon-like peptide 1 receptors in your intestines. When these receptors are activated, your body experiences a drop in appetite as well as an increase in blood sugar, among other things. Semaglutide is different from other weight loss treatments out there because of how it is administered and the fact that it is FDA approved. Semaglutide must be injected subcutaneously. It was also found to improve blood sugar in people with type 2 diabetes and can help control blood sugar in combination with other diabetes treatment you may be using, like sulfonylurea or insulin. Semaglutide is not used as an anti-diabetic medicine on its own but rather along with these other drugs to help manage your blood sugar. Because semaglutide works by manipulating your body’s GLP-1 levels, it isn’t able to give you any immediate effects after taking it, meaning that you won’t feel satisfied until a few hours later when its effects start working on your system. This may take some getting used to if you are transitioning off fast-acting diet pills or something similar.

Semaglutide, FDA-approved medications containing the active ingredient semaglutide, are designed for weight management.

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You can inject GLP-1 medications at any time during the day, without regard to meals. If your dosage is prescribed to inject weekly, you should inject your dose on the same day each week.

As with other GLP-1 (glucagon-like peptide 1) receptor agonists, adverse effects GI effects are common (~5%); the major adverse effects are gastrointestinal, including nausea, diarrhea, and vomiting. In weight loss trials, these adverse effects were generally mild to moderate and, for most patients, improved over time.